The big news is, as the New York Times reports, starting next Wednesday, May 6, the subway will shut down completely each night between 1:00 and 5:00 a.m. to allow workers to sanitize the trains. According to the Times story, during these hours the MTA will “provide free, alternative means of transit to essential workers who need to travel during that time.” There are more details about this service in the Times story linked above.
The little news is that C trains have been restored to the list of those providing “essential” service. This means there will be more service, local and express, at High Street and Jay Street-MetroTech, during the hours – early morning through evening – that the C train runs.
Apart from this there are no planned service changes directly affecting service at any local stations this weekend or coming week, other than that trains on all lines will be running less frequently than usual. Of course, we must take into account the possibility of “incidents” or “police investigations” or “signal problems” causing greater than planned delays, so it’s always best to check MTA Service Advisory for current status on any line.